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. 2018 Jan 4;14(1):e1006627. doi: 10.1371/journal.ppat.1006627

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© 2018 Armstrong-James et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — NFAT, nuclear factor of activated T cells. Phagocytosis of zymosan or C. albicans leads to Syk-dependent activation of calcium flux via PLCγ. In contrast, for A. fumigatus, phagocytosis leads to TKR9 and Btk-dependent calcineurin-NFAT activation via PLCγ. This is independent of Syk. For particulate LPS, endocytosis via CD14 leads to PLCγ-dependent calcineurin-NFAT activation.