Table 1. Important future questions in the field.

What calcineurin-independent calcium signaling pathways are important for innate fungal immunity?

Is Bruton’s tyrosine kinase a primary driver of macrophage calcium flux in response to other fungi?

Does calcineurin contribute to macrophage cell death responses to other fungi apart from A. fumigatus?

Can modulation of calcineurin signaling improve outcomes from fungal disease?

How important is calcineurin signaling for innate immunity to other nonfungal pathogens?

How does calcineurin modulate macrophage-programmed cell death responses?