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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cancer Res. 2017 Oct 24;78(1):230–245. doi: 10.1158/0008-5472.CAN-17-1961

Fig. 1. AIDS-KS spindle cells exhibit oral MSC-specific markers.

Fig. 1

(A) Paraffin-embedded sections of KS lesions from five AIDS-KS patients were subjected to immunohistochemical analyses for LANA, Nestin and CD29. (B) Two cases, one carrying the sarcoma in the palate and the other in the palm, are illustrated. H&E staining reveals typical KS histological feathers such as spindle shaped KS cells and slit-like vascular channels with erythrocytes. Immunohistochemical staining shows LANA, Nestin and CD29 in KS spindle cells. (C) Oral MSCs from periodontal ligament (PDLSC), dental pulp (DPSC) and gingiva (GMSC), along with lymphatic endothelial cells (LECs) and KSHV-infected LECs, were examined for their expression of Nestin using IFA and DAPI. KSHV infection of LECs was confirmed by IFA with an anti-LANA antibody.