Table 2.
Pathway categorization of significantly (q ≤ 0.1) differentially expressed genes in normal lung tissues from flaxseed-fed mice compared to control-fed mice
| Pathway name | Total genes in the pathway | Identified genes in the pathway | % Significant genes |
|---|---|---|---|
| Xenobiotics | 23 | 12 | 52.17 |
| Phase I | 106 | 33 | 31.13 |
| RAF/MAPK signaling | 253 | 43 | 17.00 |
| SOS-mediated signaling | 253 | 43 | 17.00 |
| IRS-mediated signaling | 329 | 51 | 15.50 |
| EGFR signaling pathway | 373 | 53 | 14.21 |
| VEGF signaling | 347 | 48 | 13.83 |
| PI3K-AKT signaling | 138 | 18 | 13.04 |
| FGFR signaling | 94 | 11 | 11.70 |
| Phase II | 103 | 12 | 11.65 |
| Cytokine signaling in Immune system | 835 | 94 | 11.26 |
| Development biology | 1066 | 111 | 10.41 |
| Detoxification of ROS | 39 | 4 | 10.26 |
| Wnt signaling | 296 | 23 | 7.77 |
| Apoptosis | 174 | 10 | 5.75 |
| Cellular response to hypoxia | 75 | 3 | 4.00 |
| Cellular response to stress | 423 | 15 | 3.55 |
| Cell cycle | 604 | 20 | 3.31 |
| Transcription regulation by TP53 | 364 | 11 | 3.02 |
| Cell cycle checkpoints | 183 | 3 | 1.64 |
| DNA repair | 293 | 4 | 1.37 |