Table 1.

Single Nucleotide Variants, Tumor Mutations, and Epidemiological Factors by NHL Subtype. Each NHL subtype harbors a distinct collection of genetic abnormalities and host/environmental risk factors.

NHL Subtype	Burkitt Lymphoma	Diffuse Large B-cell Lymphoma	Follicular Lymphoma	Mantle Cell Lymphoma	Marginal Zone Lymphoma	Lymphoplasma- cytic Lymphoma/ Waldenström’s
Key Single Nucleotide Variants	NICL*	543 total identified Newly identified: rs116446171 rs13255292 rs4733601 rs2523607 rs79480871 (Cerhan et al., 2014a; Morin et al., 2013)	rs3117222 rs9275517 rs4938573 rs5947462 rs6444305 rs17749561 rs13254990 (Skibola et al., 2014; 2012)	NICL*	rs9461741 rs2922994 (Vijai et at., 2015)
Key Tumor Mutations**	MYC (Love et al., 2012)	CECR1, MYD88 (Love et al., 2012)	CDKN2A/B (during tFL progression) (Pasqualucci et al., 2011)	ATM, CCND1, TP53 (Zhang et al., 2014; Bea et al., 2013)	BTNL2, NOTCH2 (SMZL) (Parry et al., 2013)	L265P (Ansell et al., 2014; Poulain et at., 2013) MYD88 (Ansell et al., 2014; Poulain et at., 2013)
Key Epidemiological Factors***	History of eczema alone without another atopic condition Working as a cleaner History of HCV (older patients) Those in the 75th percentile of height or higher (Mbulaiteye et al., 2014)	Increased young adult BMI History of B-cell activating autoimmune diseases HCV seropositivity Family history of NHL; higher young adult BMI Higher recreational sun exposure History of any atopic disorder Higher SES Working as a vegetable farm worker, seamstress or hairdresser (women) Low adult BMI, hormone replacement therapy beginning before age 50, oral contraceptive use before 1970 (women) Working as a handling equipment operator, lifetime alcohol consumption, previous blood transfusion (men) (Cerhan et al., 2014b)	History of Sjögren’s syndrome Family history of NHL Being over-weight as a young adult Working as a spray painter Cigarette smoking (females only) (Linet et al., 2014)	Family history of any hematological malignancy History of living on a farm (Smedby et al., 2014)	History of: Sjögren’s syndrome Systemic lupus erythematosus Peptic ulcers First degree relative with a history of a hematological malignancy HCV positivity Decreased years since quitting smoking Asthma without other atopic disorders Working as a carpenter, painter or metal-worker Hair dye use (among women) (Bracci et al., 2014)	History of Sjögren’s syndrome Systemic lupus erthematosus HCV infection Familial history of any hematologic malignancy Hay fever Working as an MD Length of time smoking cigarettes High BMI as an adult (Vajdic et al., 2014)

Note:

^*not identified in current literature;

^**most common;

^***increases risk