The mechanism towards catabolism in chondrocytes (A): Chondrocyte morphology in complete medium with or without low IL1β, IL1β, FGF2, or IL1β + FGF2. (B): Quantitative gene expression analysis of chondrocytes in complete medium with or without low IL1β, IL1β, FGF2, or IL1β + FGF2. (n = 4; **P < 0.05 to control group). (C): Quantitative FGFr1/FGFr3 gene expression ratio in all groups (n = 4; **P < 0.05 to control group). (D): Representative immunohistochemically staining of native cartilage and cartilage surrounding 0.9 mm defects for FGFr3 at 4 weeks (n = 4). (Bar = 500 μm).