Table 3.
The Qalb in individuals with normal (CSF Aβ42/Aβ40 ratio ≥0.1) and pathologic (CSF Aβ42/Aβ40 ratio <0.1) CSF signature
| Sample characteristics | Controls (N), n = 214 | Control (P), n = 77 | SCD (P), n = 57 | MCI (P), n = 121 |
|---|---|---|---|---|
| Gender F/M | 124/90 | 52/25 | 26/31 | 60/61 |
| Age, y | 72 (5) | 74 (5)∗∗ | 71 (5) | 72 (5) |
| MMSE | 29.2 (0.9) | 29.0 (0.9) | 28.1 (1.5)∗∗∗ | 26.8 (1.8)∗∗∗ |
| APOE 1 or 2 ε4 alleles | 20% | 53%∗∗∗ | 67%∗∗∗ | 68%∗∗∗ |
| Qalb | 6.0 (2.1) | 5.8 (2.4) | 5.7 (2.2) | 6.6 (4.8) |
Data are shown as mean (standard deviation) unless otherwise specified. Demographic factors and clinical characteristics were compared using 1-way analysis of variance and chi-square tests. Qalb was analyzed with univariate general linear models controlling for age and gender, compared with controls ∗∗p < 0.01, and ∗∗∗p < 0.001.
Key: Aβ, amyloid β; CSF, cerebrospinal fluid; F, female; M, male; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; N, normal CSF signature; P, pathologic CSF signature; Qalb, CSF/plasma albumin ratio; SCD, subjective cognitive decline.