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. 2017 Apr;137(4):910–920. doi: 10.1016/j.jid.2016.11.029

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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GWAS SNPs for nevus count or melanoma risk versus DNA methylation in skin tissue in cis. Regional plot of 100 kb flanking regions around the GWAS SNP of interest denoted as a striped black line. Each point is a CpG site with its P-value on the y-axis. The plots are annotated with a gene track from LocusZoom. Each point is colored according to the occurrence of genetic variants on the probe sequence (see the legend): (a) rs738322 identified for cutaneous nevi; (b) rs3768080 identified for cutaneous nevi; (c) rs45430 identified for melanoma risk; (d) rs401681 identified for melanoma risk. GWAS, genome-wide association studies; SNP, single nucleotide polymorphism.