Table 3. Antibiotic therapy for necrotizing fasciitis.

Disease classification	Antibiotic	Adult dose
Empirical therapy	Teicoplanin or	6–12 mg/kg q24 h IV
	vancomycin or	15 mg/kg q12 h IV
	linezolid	600 mg q12 h IV
	plus
	piperacillin/tazobactam or	3.375–4.5 g q8 h IV
	ertapenem or	1 g q24 h IV
	meropenem or	1 g q8 h IV
	imipenem or	500 mg q6 h IV
	cefepime	2 g q8 h IV
	plus
	metronidazole	500 mg q8 h IV
Streptococcus	Penicillin	2–4 million units q4–6 h IV
	plus
	clindamycin	600–900 mg q8 h IV
Methicillin-susceptible Staphylococcus aureus	Nafcillin or	1–2 g q4 h IV
	cefazolin	1–2 g q8 h IV
Methicillin-resistant Staphylococcus aureus	Vancomycin or	15 mg/kg q12 hr IV
	teicoplanin or	6–12 mg/kg q24 h IV
	linezolid	600 mg q12 h IV
Aeromonas hydrophilia	Ciprofloxacin or	400 mg q12 h IV
	cefotaxime or	2 g q8 h IV
	ceftriaxone	2 g q24 h IV
	plus
	doxycycline	100 mg bid PO
Vibrio vulnificus	Cefotaxime or	2 g q8 h IV
	ceftriaxone	2 g q24 h IV
	plus
	doxycycline	100 mg bid PO

IV, intravenous; PO, per os.