Table 6. Empirical antibiotic therapy for bite wound infection.

Classification	Antibiotic	Adult dose (normal kidney function)
Drug of choice	Amoxicillin/clavulanate	875/125 mg bid PO
	Ampicillin/sulbactam	1.5–3.0 g q6–8 h IV
	Piperacillin/tazobactam	3.375–4.5 g q6–8 h IV
	Ceftriaxone or	2 g q24 h IV
	cefotaxime	1–2 g q6–8 h IV
	plus
	metronidazole or	500 mg q8 h IV or 250–500 mg tid PO
	clindamycin	600 mg q6–8 h IV or 300 mg tid PO
Alternatives	Cefoxitin	1 g q6–8 h IV
	Ertapenem	1 g q24 h IV
	Moxifloxacin	400 mg q24 h IV or PO
	Doxycycline	100 mg bid PO
	Ciprofloxacin or	400 mg q12 h IV or 500–750 mg bid PO
	levofloxacin or	750 mg q24 h IV or PO
	trimethoprim-sulfamethoxazole or	TMP 5–10 mg/kg/day IV or 160–800 mg bid
	cefuroxime	1 g q12 h IV or 500 mg bid PO
	plus
	metronidazole or	500 mg q8 h IV or 250–500 mg tid PO
	clindamycin	600 mg q6–8 h IV or 300 mg tid PO

PO, per os; IV, intravenous.