Table 3. Recommended antibiotic dose and duration for acute pharyngotonsillitis caused by Streptococcus pyogenes .

Antibiotics			Route	Dose	Duration
Patients with no penicillin hypersensitivity	Preferred	Amoxicillin	Oral	50 mg/kg, once a day (Maximum 1000 mg) 25 mg/kg, twice a day	10 days
	Alternative	Amoxicillin/clavulanate	Oral	500/125 mg, 3 times a day	10 days
		Ampicillin/sulbactam	Oral	500/250 mg, 3 times a day	10 days
		Benzathine penicillin G	IM	1,200,000 units	Once
Type 4 penicillin hypersensitivity (e.g., rash)	Preferred: first-generation cephalosporins	Cephalexin	Oral	500 mg, twice a day	10 days
		Cefadroxil	Oral	1000 mg, once a day	10 days
	Alternative	Cefpodoxime	Oral	100 mg, twice a day	5 days
		Cefdinir	Oral	300 mg, twice a day	5 days
Type 1 penicillin hypersensitivity (e.g., anaphylaxis)		Clindamycin	Oral	300 mg, 3 times a day	10 days
		Azithromycin	Oral	500 mg, once a day	5 days
		Clarithromycin	Oral	250 mg, twice a day	10 days