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. 2018 Jan 4;9:68. doi: 10.1038/s41467-017-02458-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Analysis of mouse parabionts reveals the long-term residence of T cell populations in SLOs. Four weeks after parabiosis surgery, blood, cervical LNs (cLNs), mesenteric LNs (mLNs), spleen, and Peyer’s patches (Pp) were recovered and analyzed. a Diagram illustrating the experimental model. b Gating strategy to define naïve (Tnaive), memory (Tmem) and regulatory (Treg) CD4 and CD8 T cells. c CD45.1/CD45.2 dot-plots are shown for mLN CD4 Treg, Tmem and Tnaive cells from a representative CD45.1 parabiont. d CD45.1/CD45.2 dot-plots are shown for mLN CD8 Tmem and Tnaive cells from a representative CD45.1 parabiont. e Proportions of host cells (CD45.1⁺ for the CD45.1 parabiont and CD45.2⁺ for the CD45.2 parabiont) among the indicated CD4 T cell and CD8 T cell subsets recovered from blood, cLNs, mLNs, Spleen, and Pp are shown for at least ten parabiotic pairs from three independent experiments (mean ± SEM; paired t-test). f Proportions of host cells among Ly-6C⁻ and Ly-6C⁺ CD4 Treg cells. Each pair of dots represents an individual mouse (paired t-test). *p < 0.05, ***p < 0.001. ns not significant