Fig. 2.

Dual inhibitors exhibit unique activity against the CoREST complex. a Coomassie stained gel depicting the three components of the CoREST ternary complex after purification by size exclusion chromatography. b Dose response produced by inhibition of LSD1 as part of the CoREST complex by corin and structurally matched compound 7. c Inhibition curves generated for corin and MS-275 against HDAC1 as part of the CoREST complex. d Corin inhibited the deacetylation of reconstituted nucleosomes by the CoREST complex as determined by Western blot (CoREST complex = 100 nM, nucleosome = 100 nM). Data (mean ± SEM) are representative of at least two independent experiments