Fig. 6.

In vivo analysis of corin in a melanoma xenograft. a Daily IP administration of corin (30 mg kg⁻¹) potently inhibited tumor growth in an SK-MEL-5 melanoma cell mouse xenograft model over the course of a 28-day treatment regimen (n = 10 mice per condition). b Western blot depicting increases in histone H3K4 methylation and H3K9 acetylation in tumor tissue obtained from the SK-MEL-5 melanoma xenograft. c Gene expression changes induced by corin in mouse xenograft tumor tissue as determined by qRT-PCR. d Corin treatment decreased the expression of Ki67, a biomarker for cell proliferation, in mouse xenograft tumor tissue (scale = 100 µm). Data (mean ± SEM) are representative of at least two independent experiments (unpaired t test, **p < 0.01, ***p < 0.001)