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. 2017 Sep 30;68(1):19–31. doi: 10.1007/s12576-017-0571-7

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Functions of ZAG in adipose tissue. Expression of ZAG is down- or up-regulated by the negative or positive stimuli. In adipose tissue, ZAG inhibits FAS and ACC1 activity, thus resulting in decreased fatty acid synthesis. Lower level of free fatty acids together with ZAG-induced increase in adiponectin expression may significantly reduce insulin resistance. Depression of DGAT1 activity suppresses triglyceride synthesis. Together with up-regulation of HSL the latter results in lower lipid deposition in adipose tissue