Table 1.

Activities of enantiomers of each compound at human CB₁ and CB₂ receptors

Compound name	Human CB1 receptor		Human CB2 receptor		Selective indexb (CB1/CB2)
	EC50 (M)	S/R ratioa	EC50 (M)	S/R ratioa
(S)AB-FUBINACA 2-fluorobenzyl isomer	2.92 × 10−9	0.21	2.44 × 10−9	3.9	1.20
(R)AB-FUBINACA 2-fluorobenzyl isomer	1.41 × 10−8		6.27 × 10−10		22.5
(S)APP-CHMINACA	2.51 × 10−7	0.0074	8.09 × 10−9	0.017	31.0
(R)APP-CHMINACA	3.37 × 10−5		4.90 × 10−7		68.8
(S)EMB-FUBINACA	4.58 × 10−10	0.015	2.14 × 10−9	2.5	0.214
(R)EMB-FUBINACA	3.07 × 10−8		8.63 × 10−10		35.6
(S)5F-EMB-PINACA	4.96 × 10−9	0.14	6.91 × 10−9	4.1	0.718
(R)5F-EMB-PINACA	3.59 × 10−8		1.68 × 10−9		21.4
(S)MDMB-FUBICA	9.72 × 10−9	<0.0001	1.07 × 10−9	0.35	9.08
(R)MDMB-FUBICA	>1.00 × 10−4		3.10 × 10−9		>30,000
CP55940	1.28 × 10−9		1.54 × 10−10		8.3

^a S/R ratio is the EC₅₀ value ratio of an (S)-enantiomer to the corresponding (R)-enantiomer

^bSelective index is EC₅₀ ratio of the CB₁ to CB₂