Table 3.
Mean percentages of regorafenib and metabolites excreted in urine and feces following a single oral dose of 120 mg [14C]regorafenib solution
| Percent of dose (%CV) | Urine | Feces | Total |
|---|---|---|---|
| Excretion (measured radioactivity) | 19.3 (19) | 71.2 (5.3) | 90.5 (3.3) |
| Excretion by component | |||
| M-8 | 4.7 (30) | – | 4.7 (30) |
| M-7 | 12.9 (17) | 5.0 (129) | 17.9 (32) |
| M-6 | – | 14.7 (48) | 14.7 (48) |
| M-3 | – | 1.8 (36) | 1.8 (36) |
| M-4 | – | 2.2 (37) | 2.2 (37) |
| Regorafenib | – | 47.2 (18) | 47.2 (18) |
| Calculated (sum of components) | 17.7 | 70.8 | 88.5a |
aDifference from 100% is the result of unknown metabolites and radioactivity not yet excreted