Table 1.

ESCMID-ECMM Grading 2017

Category, grade		Definition
Strength of recommendation	A	Strongly supports a recommendation for use
	B	Moderate evidence to support a recommendation for use
	C	Poor evidence to support a recommendation
	D	Supports a recommendation against use
Quality of evidence—level	I	Evidence from ≥ 1 properly randomised controlled trial
	II	Evidence from ≥ 1 well-designed clinical trial, without randomisation; from cohort or case-controlled analytic studies (preferably from > 1 centre); from multiple time series; or from dramatic results from uncontrolled experiments
	III	Evidence from opinions of respected authorities, based on clinical experience, descriptive studies or reports of expert committees
Quality of evidence—index (for level II)	r	Meta-analysis or systematic review of randomised controlled trials
	t	Transferred evidence, that is, results from different patients’ cohorts, or similar immune-status situation
	h	Comparator group is a historical control
	u	Uncontrolled trial
	a	Published abstract (presented at an international symposium or meeting)