Fig. 2.

Association of the NLRP3 rs10754558 SNP with NLRP3 mRNA levels in PBMCs from patients with GA. The levels of NLRP3 mRNA in PBMCs were measured in the different genotype carriers from the GA group. The levels of the NLRP3 mRNA differed significantly among the three genotypes of rs10754558, both in patients with acute and non-acute GA (F = 13.55, 15.32, all P < 0.0001). a In patients with acute GA, the NLRP3 mRNA expression levels in 45 GG homozygotes and 45 heterozygotes carriers was significantly increased compared with 45 CC homozygotes carriers (all P < 0.01), and NLRP3 mRNA levels were higher in GG homozygotes carriers than that in CG heterozygotes carriers (P < 0.01). b In patients with non-acute GA, the NLRP3 mRNA levels were significantly reduced in the 45 GG homozygotes or 45 GT heterozygotes carriers compared with 45 CC homozygotes carriers (all P < 0.01); no difference was observed between the GG and CG genotypes (P > 0.05). The data are shown as box plots. Each box represents the upper and lower interquartile range (IQR). The whiskers represent 1.5 times the upper and lower IQRs. The ANOVA, LSD method was performed. ^a P < 0.01 in comparison with patients with the CC genotype; ^b P < 0.01 in comparison with patients with the CG genotype. The statistical significance was set at P ≤ 0.05