Table 1.

Factors underlying delayed initiation of age-appropriate treatment for CHH males.

Patient/parent factors	Delayed presentation
	Failure to attend follow-up visits
	Failure to adhere to prescribed treatment
Physician factors/errors	Belief that ‘simple reassurance’ is the only required first-line management for case of absent puberty beyond age 14
	Belief that partial puberty (testicular volume ≥4 mL) means that progression of puberty to completion is inevitable, so that patients can thus be safely discharged from follow-up
	Failure to identify or recognise the significance of ‘red flag’ features pointing to CHH over CDP
	Failure to prescribe clinically-meaningful doses of testosterone to adult men with confirmed CHH