Table 2.

Six-gene-based classification of samples based on histology compared to age, size, capsule invasion degree, vascular invasion foci, cytological diagnosis (Bethesda system) and genotype.

Sample ID	Histology	Age (years)	Size (mm)	Capsule invasion degree	Vascular invasion foci	Bethesda category	Genotype	Prediction	Probability (%)
FA1	FA	41	35	None	None	III	WT	FA	76
FA13	FA	58	28	None	None	III	WT	FA	65
FA14	FA	19	18	None	None	IV	WT	FA	65
FA2	FA	55	25	None	None	III	WT	FA	82
FA25	FA	35	34	None	None	III	WT	FA	75
FA26	FA	34	18	None	None	IV	WT	MI-FTC	51
FA3	FA	31	44	None	None	IV	WT	FA	78
FA39	FA	50	20	None	None	III	WT	FA	54
FA40	FA	47	50	None	None	III	WT	FA	91
FA41	FA	51	15	None	None	III	WT	FA	63
FA42	FA	53	10	None	None	NA	WT	FA	90
FA70	FA	40	26	None	None	III	WT	FA	79
FA80	FA	41	30	None	None	III	WT	FA	90
FA81	FA	45	36	None	None	III	WT	MI-FTC	88
FA82	FA	49	25	None	None	NA	WT	FA	58
FA83	FA	50	42	None	None	III	WT	FA	81
FA85	FA	40	28	None	None	III	WT	FA	80
FA91	FA	35	52	None	None	NA	WT	FA	100
MI-FTC19	MI-FTC	45	15	Entire	<4	III	WT	MI-FTC	80
MI-FTC22	MI-FTC	64	26	Entire	<4	III	NRAS Q61K	WI-FTC	75
							NRAS M72L
							TERT C228T
MI-FTC30	MI-FTC	34	22	Partial	None	IV	WT	MI-FTC	91
MI-FTC33	MI-FTC	59	22	Partial	<4	III	WT	MI-FTC	58
MI-FTC36	MI-FTC	63	34	Partial	<4	NA	PAX8-PPARG ex. 7	MI-FTC	62
MI-FTC50	MI-FTC	45	50	Entire	None	III	WT	MI-FTC	67
MI-FTC51	MI-FTC	69	28	Partial	None	III	WT	MI-FTC	92
MI-FTC58	MI-FTC	55	22	Partial	None	IV	WT	MI-FTC	73
MI-FTC59	MI-FTC	28	18	Entire	<4	IV	WT	MI-FTC	83
MI-FTC60	MI-FTC	42	10	Partial	<4	NA	WT	FA	56
MI-FTC61	MI-FTC	39	18	Entire	None	NA	WT	MI-FTC	84
MI-FTC92	MI-FTC	41	22	Entire	None	III	WT	MI-FTC	74
MI-FTC93	MI-FTC	38	35	Entire	None	NA	WT	FA	63
MI-FTC94	MI-FTC	72	22	Partial	<4	III	KRAS Q61R	WI-FTC	93
							TERT C228T
WI-FTC4	WI-FTC	63	38	Entire	>4	III	WT	WI-FTC	70
WI-FTC48	WI-FTC	29	15	Entire	<4	III	NRAS Q61R	WI-FTC	100
WI-FTC49	WI-FTC	63	60	Entire	>4	IV	WT	FA	72
WI-FTC5	WI-FTC	53	NA	Entire	>4	NA	NRAS Q61R	WI-FTC	100
WI-FTC69	WI-FTC	77	NA	Entire	>4	V	NRAS Q61R	WI-FTC	100
WI-FTC75	WI-FTC	73	57	Entire	>4	IV	NRAS Q61R	WI-FTC	95

Probability refers to the reliability of classification according to the distance from histological class centroids.

FA, follicular adenoma; MI-FTC, minimally invasive follicular thyroid carcinoma; NA, not available; WI-FTC, widely invasive follicular thyroid carcinoma.