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. 2017 May 18;9(1):83–90. doi: 10.1111/jdi.12674

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© 2017 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Subcutaneous administration of hydrogen gas (H₂) reduced 24‐h urine volume, urinary total protein, β2‐microglobulin, kidney weight/bodyweight ratio (Kw/Bw) and renal fibrosis resulting from diabetes. After 4 weeks of H₂ treatment, (a) 24‐h urine volume, (b) urinary total protein, (c) β2‐microglobulin and (d) Kw/Bw were detected, and (e) kidney tissues were fixed for Masson staining. The 24‐h urine volume, urinary total protein, β2‐microglobulin, Kw/Bw and renal fibrosis in the group with H₂ treatment were significantly reduced, compared with the diabetes mellitus (DM) group (n = 16 for each group). The data are expressed as mean ± SD (n = 8–16). **P < 0.01. NC, normal control group; SAH, subcutaneous administration of H₂ group.