Table 2.
Differentially expressed miRNAs with p value less than 0.05 in T cells from patients with pSS compared with the controls in the discovery cohort (two different normalisation ways were used: global mean and reference miRNAs)
| (pSS TL) vs (ctrl TL)/global mean normalisation | (pSS TL) vs (ctrl TL)/reference miRNAs normalisation | Common miRNAs/global mean and reference miRNAs | ||||
| miRNAs | Fold change | p Value | miRNAs | Fold change | p Value | |
| hsa-let-7d-3p | −2.53 | 5.07E-07 | hsa-let-7d-3p | −2.58 | 1.97E-07 | hsa-let-7d-3p |
| hsa-miR-28–5 p | 1.36 | 3.78E-05 | hsa-miR-28–5 p | 1.34 | 3.81E-04 | hsa-miR-28–5 p |
| hsa-miR-378a-3p | −1.33 | 7.32E-04 | hsa-miR-378a-3p | −1.36 | 1.15E-04 | hsa-miR-378a-3p |
| hsa-miR-26a-5p | −1.28 | 9.50E-04 | hsa-miR-26a-5p | −1.30 | 1.23E-03 | hsa-miR-26a-5p |
| hsa-miR-425–3 p | −1.33 | 1.04E-03 | hsa-miR-425–3 p | −1.36 | 1.09E-03 | hsa-miR-425–3 p |
| hsa-miR-486–5 p | 1.56 | 6.45E-03 | hsa-miR-486–5 p | 1.53 | 0.013 | hsa-miR-486–5 p |
| hsa-miR-181c-5p | 1.43 | 7.33E-03 | hsa-miR-181c-5p | 1.40 | 0.022 | hsa-miR-181c-5p |
| hsa-miR-30b-5p | −1.17 | 0.010 | hsa-miR-30b-5p | −1.19 | 0.024 | hsa-miR-30b-5p |
| hsa-miR-140–3 p | 1.14 | 0.013 | hsa-miR-140–3 p | 1.12 | 0.043 | hsa-miR-140–3 p |
| hsa-miR-296–5 p | 1.27 | 0.013 | hsa-miR-296–5 p | 1.25 | 0.044 | hsa-miR-296–5 p |
| hsa-miR-30c-5p | −1.12 | 0.014 | hsa-miR-30c-5p | −1.14 | 8.19E-03 | hsa-miR-30c-5p |
| hsa-miR-155–5 p | 1.30 | 0.014 | hsa-miR-155–5 p | 1.27 | 0.013 | hsa-miR-155–5 p |
| hsa-miR-31–3 p | −1.43 | 0.015 | hsa-miR-31–3 p | −1.46 | 0.017 | hsa-miR-31–3 p |
| hsa-miR-598 | −1.31 | 0.015 | hsa-miR-598 | −1.34 | 0.017 | hsa-miR-598 |
| hsa-miR-222–3 p | 1.22 | 0.018 | hsa-miR-222–3 p | 1.19 | 0.046 | hsa-miR-222–3 p |
| hsa-miR-18a-3p | 1.37 | 0.028 | hsa-miR-18a-3p | 1.34 | 0.043 | hsa-miR-18a-3p |
| hsa-let-7e-5p | −1.28 | 0.032 | hsa-let-7e-5p | −1.30 | 0.020 | hsa-let-7e-5p |
| hsa-miR-194–5 p | 1.13 | 0.036 | ||||
| hsa-miR-361–3 p | 1.32 | 0.037 | ||||
| hsa-miR-152 | 1.32 | 0.037 | ||||
| hsa-miR-374a-5p | −1.21 | 0.037 | hsa-miR-374a-5p | −1.24 | 0.041 | hsa-miR-374a-5p |
| hsa-miR-22–3 p | 1.34 | 0.038 | ||||
| hsa-miR-665 | −1.42 | 0.039 | hsa-miR-665 | −1.44 | 0.029 | hsa-miR-665 |
| hsa-let-7g-5p | 1.10 | 0.039 | ||||
| hsa-let-7i-5p | 1.12 | 0.040 | ||||
| hsa-miR-107 | 1.18 | 0.041 | ||||
| hsa-miR-27b-3p | −1.27 | 0.041 | hsa-miR-27b-3p | −1.30 | 0.034 | hsa-miR-27b-3p |
| hsa-miR-150–5 p | 1.15 | 0.045 | ||||
| hsa-miR-16–5 p | 1.14 | 0.045 | hsa-miR-16–5 p | 1.12 | 0.037 | hsa-miR-16–5 p |
| hsa-miR-454–3 p | 1.15 | 0.045 | ||||
| hsa-miR-324–3 p | 1.12 | 0.047 | ||||
| hsa-miR-23b-3p | −1.22 | 0.038 | ||||
| hsa-miR-505–3 p | −1.36 | 0.044 | ||||
| hsa-miR-766–3 p | −1.17 | 0.029 | ||||
‘MiRNAs in grey’ represent those found differentially expressed by one way of normalisation only. Nominal p values without correction for multiple comparisons are shown.
miRNA, microRNA; pSS, primary Sjögren’s syndrome; TL, T lymphocytes.