Table II.

Results of GO and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the 135 downregulated genes containing hypermethylated regions.

Category	Term	P-value	Gene count	Genes
BP	GO:0006468~protein amino acid phosphorylation	0.0021	14	STK10, DRD4, PTPRA, MKNK2, PRKCH, ADRBK1, FES, TRIB2, CSNK2A2, EPHB6, TNK2, CD6, MAP3K12, AKT2
	GO:0006796~phosphate metabolic process	0.0087	16	STK10, DRD4, EPM2A, PTPRA, MKNK2, PRKCH, ADRBK1, FES, TRIB2, CSNK2A2, EPHB6, TNK2, CD6, MAP3K12, AKT2, DUSP6
	GO:0006793~phosphorus metabolic process	0.0087	16	STK10, DRD4, EPM2A, PTPRA, MKNK2, PRKCH, ADRBK1, FES, TRIB2, CSNK2A2, EPHB6, TNK2, CD6, MAP3K12, AKT2, DUSP6
	GO:0016310~phosphorylation	0.0096	14	STK10, DRD4, PTPRA, MKNK2, PRKCH, ADRBK1, FES, TRIB2, CSNK2A2, EPHB6, TNK2, CD6, MAP3K12, AKT2
	GO:0006357~regulation of transcription from RNA polymerase II promoter	0.0113	13	CDKN1C, GATA2, SORBS3, MEIS2, E2F4, CRTC1, TFAP2B, GFI1, TCEA2, LRRFIP1, ELL3, NtnxbR0B1, ZBTB38
CC	GO:0044459~plasma membrane part	0.0118	27	FXYD1, OCLN, CLDN3, SLC6A20, DRD4, ADRBK1, PRR7, SORBS3, EPHB6, ANK1, ST3GAL5, ITGB7, GRIN2D, CD6, SLC43A1, KCNQ1, SLC1A1, HCN2, CR1, PTPRA, MAOB, TSPAN13, ACTN3, LSP1, AP2A2, MPL, SPTAN1
	GO:0005887~integral to plasma membrane	0.0166	17	FXYD1, HCN2, CR1, CLDN3, SLC6A20, DRD4, PTPRA, TSPAN13, EPHB6, ST3GAL5, GRIN2D, ITGB7, MPL, CD6, KCNQ1, SLC1A1, SLC43A1
	GO:0031226~intrinsic to plasma membrane	0.0201	17	FXYD1, HCN2, CR1, CLDN3, SLC6A20, DRD4, PTPRA, TSPAN13, EPHB6, ST3GAL5, GRIN2D, ITGB7, MPL, CD6, KCNQ1, SLC1A1, SLC43A1
	GO:0005626~insoluble fraction	0.0247	13	DES, JPH2, BACE2, GRIN2D, EPHX1, TSPAN13, ADRBK1, LTC4S, NR0B1, SLC1A1, MAP3K12, SPTAN1, AKT2
	GO:0000267~cell fraction	0.0336	15	JPH2, TSPAN13, EPHX1, ADRBK1, LTC4S, NR0B1, DES, BACE2, GRIN2D, GPX3, SLC1A1, MAP3K12, AKT2, SPTAN1, DUSP6
MF	GO:0008134~transcription factor binding	0.0009	13	ZNF274, E2F4, CRTC1, NR0B1, GATA2, SORBS3, MEIS2, DIP2C, NCOA4, GPX3, TFAP2B, SOX17, DDAH2
	GO:0048037~cofactor binding	0.0156	7	SDHA, CRYL1, ME3, ALDH1L1, ACADS, GPT, OAT
	GO:0005200~structural constituent of cytoskeleton	0.0220	4	SORBS3, ANK1, DES, SPTAN1
	GO:0004672~protein kinase activity	0.0247	11	CSNK2A2, EPHB6, STK10, MKNK2, PRKCH, ADRBK1, TNK2, FES, MAP3K12, TRIB2, AKT2
Pathway	hsa04530: Tight junction	0.0036	7	CSNK2A2, OCLN, CLDN3, PRKCH, ACTN3, SPTAN1, AKT2

BP, biological process; CC, cell component; MF, molecular function; GO, Gene Ontology; hsa, Homo sapiens.