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. 2017 Sep 28;14(6):6650–6658. doi: 10.3892/ol.2017.7099

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Copyright: © Tamura et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Immunohistochemical analysis of SHISA2 in clinical PC tissues. Immunoreactivity with anti-SHISA2 antibody was observed in high-grade PCs with high GS, exhibiting strong positive immunostaining in the cytoplasm of PC cells. (A) Representative image of PC cells with GS 5+5 (magnification, ×200). (B) Representative image of PC cells with GS 3+4 (magnification, ×200). Adjacent NP epithelium revealed a weak or no signal for SHISA2. (C) Association between SHISA2 expression and GS in PC. A significant association was determined between the expression level of SHISA2 and GS, using univariate Spearman's rank analysis (r=0.5287; P<0.0001). SHISA2, shisa family member 2; PC, prostate cancer; GS, Gleason score; NP, normal prostate.