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. 2017 Oct 10;14(6):7311–7317. doi: 10.3892/ol.2017.7157

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Copyright: © Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Expression level of miR-124 in human ovarian tissues and PDCD6 is a target of miR-124. (A) Representative hematoxylin and eosin staining of ovarian tumor tissue specimens (magnification, ×200). (B) Representative hematoxylin and eosin staining of non-neoplastic ovarian tissue specimens (magnification, ×200). (C) Expression of miR-124 was detected in 30 human ovarian cancer tissues by polymerase chain reaction. Data are presented as log2 values of the change in ovarian tumor tissues relative to non-neoplastic ovarian tissues. (D) The expression of miR-124 in ovarian cancer tissues was decreased compared with in non-neoplastic ovarian tissues (***P<0.001). (E) The putative association between PDCD6 and miR-124 was revealed by TargetScan. (F) The dual-luciferase reporter assay revealed regulation of PDCD6 by miR-124, including wild-type PDCD6 or mutant PDCD6 3′-UTR transfected with or without miR-124 mimics or scramble. (G) Diagram of the PDCD6 3′-UTR with potential binding-sites for miR-124. The data from three in vitro independent experiments are presented (**P<0.01). NC, negative control; miR, microRNA; UTR, untranslated region; mut, mutant; PDCD6, programmed cell death 6.