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. 2017 Sep 28;14(6):6345–6354. doi: 10.3892/ol.2017.7091

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — ZNF70 is a candidate target gene of miR-1269a and serves as a tumor suppressor in gastric cancer cells. (A) Sequence alignment of miR-1269a and putative ZNF70-3′UTR. (B) Western blot analysis of expression levels of ZNF70 in HGC-27 and MGC-803 cells that were transfected with miR-control, miR1269a mimics and miR-1269a-variant mimics and their inhibitors. GAPDH served as the loading control. (C) Western blot analysis of ZNF70 in ZNF70-siRNA-transfected cells. GAPDH served as the loading control. (D) The effects of ZNF70 on miR-1269a-mediated HCC proliferation as analyzed by cell-counting kit-8 assay. *P<0.05, **P<0.01 and ***P<0.001. ZNF70, zinc-finger protein 70; siRNA, small-interfering RNA; miRNA, microRNA; OD, optical density; UTR, untranslated region.

Figure 3. — ZNF70 is a candidate target gene of miR-1269a and serves as a tumor suppressor in gastric cancer cells. (A) Sequence alignment of miR-1269a and putative ZNF70-3′UTR. (B) Western blot analysis of expression levels of ZNF70 in HGC-27 and MGC-803 cells that were transfected with miR-control, miR1269a mimics and miR-1269a-variant mimics and their inhibitors. GAPDH served as the loading control. (C) Western blot analysis of ZNF70 in ZNF70-siRNA-transfected cells. GAPDH served as the loading control. (D) The effects of ZNF70 on miR-1269a-mediated HCC proliferation as analyzed by cell-counting kit-8 assay. *P<0.05, **P<0.01 and ***P<0.001. ZNF70, zinc-finger protein 70; siRNA, small-interfering RNA; miRNA, microRNA; OD, optical density; UTR, untranslated region.