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. 2017 Oct 26;102(1):136–141. doi: 10.1136/bjophthalmol-2017-310498

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Autosomal-dominant cone-rod dystrophy progression. Top row: unaffected sibling IV-4 and affected patients IV-2 and IV-5, all teenaged, are virtually indistinguishable at funduscopic scale. Bottom row: III-1, age 40, shows stippled retinal pigment epithelial (RPE) atrophy. II-6, age 62, shows advanced RPE atrophy in the central macula. (A) Adaptive optics scanning light ophthalmoscopy at the margin of the atrophic area in II-6, indicated by the white square on the fundus photograph. No photoreceptors are identified.