Table II.
Drug sensitivity in parental A549 and A549-CHI-R cells.
| A549 | A549-CHI-R | ||||
|---|---|---|---|---|---|
| Drug | IC50 | 95% CI | IC50 | 95% CI | Resistance index |
| Chidamide | 9.07 | 6.00–11.32 | 78.34 | 51.30–111.87 | 8.64 |
| 5-fluorouracil | 4.03 | 2.09–7.75 | 5.17 | 2.77–7.58 | 1.28 |
| Cisplatin | 9.13 | 8.90–9.37 | 7.87 | 5.75–10.76 | 0.86 |
| Gemcitabine | 0.21 | 0.01–3.65 | 2.25 | 1.67–3.03 | 10.55 |
| Vinorelbine | 31.06 | 11.32–85.17 | 411.00 | 282.10–598.80 | 13.23 |
| Paclitaxel | 0.89 | 0.11–1.98 | 123.40 | 6.00–260.00 | 123.40 |
Sensitivity to the drugs was determined by MTT assay after 72 h. Resistance index is a comparison between the IC50 for the drug in A549-CHI-R cells and the IC50 for the parental A549 cells. A549-CHI-R, chidamide-resistant A549 cells; CI, confidence interval.