Table III.
Effects of TAX or VNR on the cell cycle distribution in parental A549 and A549-CHI-R cells.
| A549 cells, % | A549-CHI-R cells, % | |||||
|---|---|---|---|---|---|---|
| Cell cycle phase | Ctrl | TAX | VNR | Ctrl | TAX | VNR |
| Sub-G1 | 1.7 | 0.3 | 0.5 | 0.2 | 0.1 | 0.1 |
| G1 | 60.2 | 15.1 | 10.8 | 53.4 | 34.8 | 41.7 |
| S | 9.9 | 6.9 | 9.3 | 15.9 | 13.0 | 15.9 |
| G2/M | 28.2 | 77.7 | 79.4 | 30.5 | 52.1 | 42.3 |
Cell cycle distribution was examined by propidium iodide staining and analyzed with fluorescence-activated cell sorting. Data represent the results of three independent experiments. TAX, paclitaxel; VNR, vinorelbine; Ctrl, control; A549-CHI-R, chidamide-resistant A549 cells.