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. 2017 Oct 12;14(6):7031–7044. doi: 10.3892/ol.2017.7177

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Copyright: © Jia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Correlation between the mRNA expression of NLRP3 molecules and cytokines. (A) The mRNA expression of NLRP3 inflammasome molecules in PBMCs and effector cytokines in PBBCs were positively correlated in ND patients. Additionally, PBBC IL-1β mRNA levels demonstrated a positive correlation with IL-18. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells. Correlation between the mRNA expression of NLRP3 molecules and cytokines. (B) In the PBMCs of CR patients, the NLRP3 mRNA level was positively correlated with ASC and IL-1β mRNA level. The relative level of ASC mRNA was positively correlated with caspase-1 and IL-18 mRNA levels. (C) In the PBMCs of controls, a positive correlation between NLRP3 and ASC relative mRNA expression was identified. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells. Correlation between the mRNA expression of NLRP3 molecules and cytokines. (D) In BMMCs of ND patients it was identified that NLRP3 expression level was positively correlated with ASC and caspase-1, and that ASC expression was positively correlated with the caspase-1 mRNA level. IL-18 mRNA in BMMCs was positively correlated with the relative ASC mRNA level. IL-1β and IL-18 mRNA levels were positively correlated with the caspase-1 mRNA level. The IL-1β level was also positively correlated with the level of IL-18 mRNA. (E) In the BMMCs of CR patients, the only significant positive correlation to be identified was between ASC and caspase-1 mRNA levels. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells.

Figure 3. — Correlation between the mRNA expression of NLRP3 molecules and cytokines. (A) The mRNA expression of NLRP3 inflammasome molecules in PBMCs and effector cytokines in PBBCs were positively correlated in ND patients. Additionally, PBBC IL-1β mRNA levels demonstrated a positive correlation with IL-18. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells. Correlation between the mRNA expression of NLRP3 molecules and cytokines. (B) In the PBMCs of CR patients, the NLRP3 mRNA level was positively correlated with ASC and IL-1β mRNA level. The relative level of ASC mRNA was positively correlated with caspase-1 and IL-18 mRNA levels. (C) In the PBMCs of controls, a positive correlation between NLRP3 and ASC relative mRNA expression was identified. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells. Correlation between the mRNA expression of NLRP3 molecules and cytokines. (D) In BMMCs of ND patients it was identified that NLRP3 expression level was positively correlated with ASC and caspase-1, and that ASC expression was positively correlated with the caspase-1 mRNA level. IL-18 mRNA in BMMCs was positively correlated with the relative ASC mRNA level. IL-1β and IL-18 mRNA levels were positively correlated with the caspase-1 mRNA level. The IL-1β level was also positively correlated with the level of IL-18 mRNA. (E) In the BMMCs of CR patients, the only significant positive correlation to be identified was between ASC and caspase-1 mRNA levels. NLRP3, NLR family pyrin domain-containing 3; PBMCs, peripheral blood mononuclear cells; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; BMMCs, bone marrow mononuclear cells.