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. 2017 Oct 12;14(6):7031–7044. doi: 10.3892/ol.2017.7177

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Copyright: © Jia et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Correlations between NLRP3-related molecules and the Th-associated molecule AHR. (A) In the ND group, NLRP3, caspase-1 and IL-1β mRNA levels were positively correlated with AHR expression in the BM. (B) In CR patients, caspase-1 and IL-1β mRNA level were positively correlated with the relative level of AHR mRNA in the BM. (C) In ND patients, the expression of NLRP3, ASC, caspase-1, IL-18 and IL-1β mRNA were positively correlated with the relative AHR mRNA level in PBMCs. NLRP3, NLR family pyrin domain-containing 3; Th, T-helper cell; AHR, aryl hydrocarbon receptor; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; PBMCs, peripheral blood mononuclear cells. Correlations between NLRP3-related molecules and the Th-associated molecule AHR. (D) In PBMCs of the CR group, the levels of all NLRP3 inflammasome molecule and effector cytokine mRNA levels were positively correlated with the relative AHR mRNA level. (E) In the control group, the AHR level was observed to be negatively correlated with the caspase-1 mRNA level in PBMCs. NLRP3, NLR family pyrin domain-containing 3; Th, T-helper cell; AHR, aryl hydrocarbon receptor; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; PBMCs, peripheral blood mononuclear cells.

Figure 5. — Correlations between NLRP3-related molecules and the Th-associated molecule AHR. (A) In the ND group, NLRP3, caspase-1 and IL-1β mRNA levels were positively correlated with AHR expression in the BM. (B) In CR patients, caspase-1 and IL-1β mRNA level were positively correlated with the relative level of AHR mRNA in the BM. (C) In ND patients, the expression of NLRP3, ASC, caspase-1, IL-18 and IL-1β mRNA were positively correlated with the relative AHR mRNA level in PBMCs. NLRP3, NLR family pyrin domain-containing 3; Th, T-helper cell; AHR, aryl hydrocarbon receptor; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; PBMCs, peripheral blood mononuclear cells. Correlations between NLRP3-related molecules and the Th-associated molecule AHR. (D) In PBMCs of the CR group, the levels of all NLRP3 inflammasome molecule and effector cytokine mRNA levels were positively correlated with the relative AHR mRNA level. (E) In the control group, the AHR level was observed to be negatively correlated with the caspase-1 mRNA level in PBMCs. NLRP3, NLR family pyrin domain-containing 3; Th, T-helper cell; AHR, aryl hydrocarbon receptor; ND, newly diagnosed; IL, interleukin; CR, complete remission; ASC, apoptosis-associated speck-like protein; PBMCs, peripheral blood mononuclear cells.