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. 2018 Jan 5;131(1):75–81. doi: 10.4103/0366-6999.221263

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Characterization of the retinal vasculature in the nondiabetic control and STZ-induced diabetic mice. Freshly dissected retinas were immediately fixed and stained with an endothelial cell marker and visualized. Nondiabetic mice had an organized retinal vascular branching pattern (a). After 18 weeks of diabetes, the vascular distribution in the retinas was dense and disorganized (b), but this improved after LIF treatment (c) (bar: 100 μm). STZ: Streptozotocin; LIF: Leukemia inhibitory factor.