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. 2018 Jan 5;131(1):75–81. doi: 10.4103/0366-6999.221263

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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LIF acts via phosphorylation of STAT3 (p-STAT3). (a) Histogram of the relative protein level of p-STAT3/GAPDH shows that the value of P-STAT3/GAPDH was statistically increased in the LIF-treated group (n = 4), compared with the diabetic control group (t = 3.85, P = 0.019, n = 4) and the normal control group (t = −3.20, P = 0.019, n = 4). It is significant among the groups (F = 6.40, P = 0.018). *P < 0.05. (b) Histogram of STAT3/GAPDH shows that for the value of STAT3/GAPDH, there was no significance among the groups. (c) A representative Western blotting shows obvious STAT3 activation at 2 days after intravitreal injection of LIF. LIF: Leukemia inhibitory factor; DM: Diabetic model; STAT3: Signal transducer and activator of transcription 3; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.