Table IV.

Multivariate analysis of the association of prognosis with clinicopathological parameters, and TIM-3 and galectin-9 expression, in patients with esophageal squamous cell carcinoma.

Parameters	Hazard ratio	95% confidence interval	P-value
Tumor size (≥5 vs. <5 cm)	0.592	0.169–2.067	0.411
TNM stage (II vs. III)	0.148	0.022–1.007	0.051
Lymph node metastasis (yes vs. no)	1.625	0.257–10.284	0.051
Depth of invasion (TI/2 vs. T3)	0.803	0.201–3.206	0.756
Pathological type (ulcerated vs. non-ulcerated)	1.670	0.522–5.345	0.387
Differentiation (poor vs. moderate/well)	1.094	0.307–3.900	0.890
TIM-3 expression (HEG vs. LEG)	1.102	0.292–4.157	0.886
Galectin-9 expression (HEG vs. LEG)	0.905	0.189–4.322	0.900

TIM-3, T-cell immunoglobulin and mucin-domain containing-3; TNM, Tumor-Node-Metastasis; HEG, high-expression group; LEG, low-expression group.