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. 2017 Oct 16;14(6):7753–7758. doi: 10.3892/ol.2017.7190

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Copyright: © Mei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miR-1470 induces cell senescence via the apoptotic Bcl-2 signaling pathway. (A) Cell senescence was analyzed by β-galactosidase staining at 48 h post-transfection. Representative images of senescent cells. (B) Number of senescent cells. ***P<0.001. (C) The expression levels of pro-caspase-12, pro-caspase-3, Bcl-2 and BAX were determined by western blotting at 48 h post-transfection and normalized to that of β-actin. (D) The levels of pro-caspase-12, pro-caspase-3 and Bcl-2 were significantly decreased and that of BAX was significantly increased in cells transfected with miR-1470 inhibitor when compared with the cells transfected with NC. Results represent the mean ± standard deviation of at least three independent experiments. ***P<0.001.