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. 2017 Nov 8;131(1):30–38. doi: 10.1182/blood-2017-06-741058

Table 1.

Examples of BsAbs for hematological malignancies

Target BsAbs format (molecule name) Reference
B-cell malignancies
 CD19 BiTE (blinatumomab) 54, 74, 75
 CD19 DART (MGD011, duvortuxizumab) 47
 CD19 Chemically crosslinked 45
 CD20 BiTE 44
 CD20 Chemically crosslinked (CD20bi) 43, 66-68
 CD20 Knobs into hole 42
 CD20 Diabody 37, 38
 CD20 Triomab (FBTA05, lymphomun) 36, 39, 40, 64
 CD20 Heterodimeric (REGN1979) 41
Multiple myeloma
 BCMA BiTE 51
 BCMA Chemically crosslinked 49
 BCMA Knobs into hole/asymmetric (EM801) 52
 CD138 BiTE-Fc 50
 Target of Wue-1 BiTE 48
 FcRH5 Knobs into hole 11
Myeloid malignancies
 CD33 BiTE 23, 25-28
 CD33 Tetravalent tandem diabody 32
 CD123 DART (MGD006) 30, 31
 CD123 BiTE (AMG 330) 24
 CD123 Duobody (JNJ-63709178) 46
 CLL1 Knobs into hole 33
 CLL1 Chemically crosslinked 29
 WT1 BiTE 21
 Flt3 BiTE, Fabsc 20
 CD13 Chemically crosslinked 22

DART, dual-affinity retargeting; Fabsc, fragment antigen binding single chain.