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. 2017 Oct 19;131(1):108–120. doi: 10.1182/blood-2017-07-791608

Figure 3.

Figure 3.

CD8 coreceptor enhances the function of class I–restricted, HA-1 TCR–transduced CD4+T cells. (A) Intracellular cytokine assay showing IL-2 and IFN-γ production by CD8+ T cells (left) and CD4+ T cells (right) transduced with HA-1 TCR2 LV (upper panels) or HA-1 TCR2-CD8 coreceptor LV (lower panels) in response to HLA-A2+/HA-1+ AML or HLA-A2+/HA-1– AML; (B) carboxyfluorescein diacetate succinimidyl ester (CFSE) assay showing proliferation of CD8+ T cells (left) and CD4+ T cells (right) transduced with HA-1–specific TCR2 LV (upper panels) or HA-1 TCR2-CD8 coreceptor LV (lower panels) in response to HLA-A2+/HA-1+ primary AML (green and blue), HLA-A2+/HA-1– AML (red), or media control (orange).