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. 2017 Oct 19;131(1):108–120. doi: 10.1182/blood-2017-07-791608

Figure 6.

Figure 6.

Evaluation of clinical-scale iC9-HA-1TCR2-RQR-CD8–transduced T cells. Evaluation of iC9-HA-1TCR2-RQR-CD8–transduced (transduced) CD8+ (left) and CD4+ (right) T cells. (A) Growth of transduced T cells. (B) HA-1 TCR multimer binding and CD34 expression on transduced T cells by flow cytometry with HA-1/HLA-A2 multimer staining. (C) Expression of costimulatory and homing molecules on T cells at the time of the apheresis (gray), after CD45RA depletion (light green), and after transduction and expansion (blue) (n = 5). (D-E) Expression of “exhaustion” markers on HA-1 TCR CD8+ and CD4+ in the final cell product (n = 3) (D) and a representative example (E).