Figure 4.

Metformin and DDP inhibit the cell viability of ovarian cancer HO-8910 cells. Cell viability was measured using a cell proliferation and cytotoxicity assay. HO-8910 cells were treated with (A) metformin (0.01, 0.5, 1, 5, and 10 mM) or (B) DDP (5 µM) alone or in combination with metformin (0.5, 1, and 5 mM metformin plus 5 µM DDP) (B) for 0, 24, 48 and 72 h to examine their effects on cell proliferation. **P<0.01 and ***P<0.001 vs. control. ^#P<0.05 and ^###P<0.001 vs. DDP. DDP, cisplatin.