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PI3K/Akt signaling pathway is involved in the silibinin-induced inhibition of migration and invasion. Cells were treated with 20 µM silibinin, 10 µM LY294002, both or vehicle (DMSO). Cell migration was assessed by (A and B) wound healing assay and (C and D) Transwell migration and invasion assays were used to confirm cell invasion and migration. *P<0.05 vs. control unless otherwise stated. PI3K/Akt, phosphatidylinositol 3-kinase/protein kinase B; SB, silibinin; LY, LY294002.
