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. 2018 Jan 5;17:1. doi: 10.1186/s12943-017-0753-1

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Expression of APC is often decreased and inversely correlated with miR-494 expression in human CRC tissues. a Immunohistochemical staining of APC in tumor tissue and corresponding normal colonic epithelium. Normal epithelium shows vesicular brown cytoplasmic APC staining. This staining is nearly absent in the tumor tissue. b APC mRNA expression is frequently decreased in tumor tissues when compared to the matched non-cancerous tissues, as evaluated by real-time PCR. c The relative levels of miR-494 expression were plotted against the relative levels of APC mRNA expression