Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 5;17:1. doi: 10.1186/s12943-017-0753-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 6 — APC is functionally involved in miR-494–induced β-catenin signaling activity of CRC cells. a Dual luciferase experiment demonstrating the effects on Top/Fop reporter activity in the indicated cells. Values were normalized to a renilla transfection control. The figure shown is representative of at least three independent experiments. b Dual luciferase assay showing the effects on a c-Myc reporter construct in the indicated cells. c Dual luciferase assay showing the effects on a cyclin D1 reporter construct in the indicated cells. d Dual luciferase experiment demonstrating the effects on Top/Fop reporter activity in the indicated cells following miR-494 downregulation. e Dual luciferase assay showing the effects on a c-Myc reporter construct in the indicated cells following miR-494 downregulation. f Dual luciferase assay showing the effects on a cyclin D1 reporter construct in the indicated cells following miR-494 downregulation. g APC western blot of the indicated cells. (**, P < 0.01, Student’s t-test, n = 3 independent experiments)