Table V.
Characteristics of histopathology and immunophenotype.
| Patient no. | Specimen | Histopathology | Main immunophenotype | Final diagnosis |
|---|---|---|---|---|
| 1 | Partial pleura | Lymphoma cells infiltrated around reactive B-cell follicles external to a preserved follicle mantle, in a marginal zone distribution and spread out to form larger confluent area. | CD20+, CD3−, CD5−, CD10−, Ki67 <5% | MALT lymphoma |
| 2 | Partial pleura | Some large atypical cells in necrosis. | CD20+, CD79a+, CD3−, CD10+, BCL2+, Ki67=40% | Diffuse large B−cell lymphoma |
| 3 | Partial pleura | Diffused small cell neoplasm, which have slightly irregular nuclei with moderately dispersed chromatin non−conspicuous nucleoli. | CD20+, CD3−, CD5−, CD10−, CD23−, CD21−, Ki67=10% | MALT lymphoma |
| 4 | Partial pleura | Diffused small cell neoplasm, which haves lightly irregular nuclei with moderately dispersed chromatin conspicuous nucleoli. | CD20+, CD79a+, CD3−, CD5−, CD10 (−), Ki67=20% | MALT lymphoma |
| 5 | Partial pleura | Lymphoma cells infiltrated around reactive B−cell follicles external to a preserved follicle mantle, in a marginal zone distribution and spread out to form larger confluent area. | CD20+, CD79a+, CD3−, CD5−, CD10−, BCL2+, Ki67=10% | MALT lymphoma |
| 6 | Partial pleura | Diffused small cell neoplasm, which have slightly irregular nuclei with moderately dispersed chromatin conspicuous nucleoli. | CD20+, CD3−, CD5+, CD23+, Calretinin−, Ki67=20% | Small lymphocytic lymphoma |
| 7 | Partial pleura | The neoplastic cells are of medium size with a high nuclear cytoplasmic ratio and with finely dispersed chromatin and relatively prominent nucleoli. | CD3+, CD5+, CD4+, CD20−, TdT+, CK−, PAX5−, Ki67=50% | T lymphoblastic lymphoma |
| 8 | Partial pleura | The neoplastic cells are of small size with a high nuclear cytoplasmic ratio and with condensed nuclear chromatin and no evident nucleoli. | CD3+, CD5+, CD20−, TdT+, CK19−, TTF1−, CD56−, Syn−, CK−, PAX5−, Ki67=90% | T lymphoblastic lymphoma |
| 9 | Partial pleura | Atypical lymphatic cell infiltrates in fibrous tissue. | CD20+, CD3−, CD5−, CD10−, BCL6−, Ki67=10% | MALT lymphoma |
| 10 | Partial pleura | Mesothelial cell and fibroblastic proliferation with focal lymphocytes infiltrates. | Not done | Follicular lymphoma |
| Lymph nodes | Closely packed follicles efface the nodal architecture. Neoplastic follicles are poorly defined and absent mantle zones. | CD20+, CD79a+, CD3−, CD5−, CD10+, BCL2+, BCL6+, Ki67=25% |
MALT lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; TdT, terminal deoxynucleotidyl transferase; CD, cluster of differentiation; CK, creatine kinase; PAX5, paired box gene 5; TTF1, thyroid transcription factor 1; Syn, synapsin; BCL, B-cell lymphoma.