Figure 4.

The new FunCoup network viewer, showing the comparative interactomics feature. The network of the query in H. sapiens (orange circles) is linked to orthologous networks in M. musculus (blue circles) and B. subtilis (red circles). As query we used the 4 human genes, LACTB2, ADH5, GOT2 and GPI, which have been identified as an evolutionarily conserved ancient metazoan protein complex. The query genes and their orthologs are highlighted with bold black border, and the orthology relation between genes is represented using green dashed lines whereas gray solid lines are functional associations within a species.