Fig. 1.

Adjusted survival curve from a Cox proportional hazard model according to limb amputation status and renal function status. a Compared to the minor LEA group, the adjusted hazard ratio for mortality was 1.80 (95% CI 1.05–3.09, P = 0.03) for those with major LEAs. b Compared to the normal renal function group, the adjusted hazard ratio for mortality was 0.87 (95% CI 0.48–1.59, P = 0.66) for those with CKD and 2.09 (95% CI 0.99–4.41, P = 0.05) for those undergoing dialysis. Covariates included continuous variables of age, diabetes duration, and HbA1c; and categorical variables of hypertension, major adverse cardiac events, renal function, ABI value and limb amputation status