Table 1.
Demographics and clinical characteristics of the patients with diabetes and infectious foot gangrene and risk factors for mortality in a Cox proportional hazards model (Total number: 157)
| Characteristic | Mean (standard deviation) or Number (%) | Multivariate+ analysis | ||
|---|---|---|---|---|
| Mortality HR (95% CI) | P value | |||
| Age (years) | 66.8 | (±10.8) | 1.04*(1.01–1.06) | 0.01 |
| Gender | 0.37 | |||
| Female | 58 | (36.9%) | 1 | |
| Male | 99 | (63.1%) | 0.79 (0.46–1.33) | |
| Diabetes duration (years) | 12.8 | (±8.4) | 1.14 (0.92–1.43) | 0.24 |
| Smoking status | 34 | (21.7%) | 1.48 (0.73–3.01) | 0.28 |
| Hypertension | 111 | (70.7%) | 1.06 (0.63–1.80) | 0.83 |
| Major adverse cardiac events | 52 | (33.1%) | 1.48 (0.88–2.50) | 0.14 |
| Abnormal ABI | 104 | (66.2%) | 1.28 (0.67–2.42) | 0.46 |
| Renal function | ||||
| Normal renal function (eGFR ≥60) |
58 | (36.9%) | 1 | |
| Chronic kidney disease (eGFR <60) |
59 | (37.6%) | 0.87 (0.48–1.59) | 0.66 |
| Dialysis | 40 | (25.5%) | 2.09^(0.99–4.41) | 0.05 |
| HbA1c (%) | 9.4 | (±2.7) | 1.02 (0.92–1.13) | 0.71 |
| Limb amputation status | ||||
| Minor LEA | 67 | (42.7%) | 1 | |
| Major LEA | 90 | (57.3%) | 1.80*(1.05–3.09) | 0.03 |
*Significance: P value <0.05
^Borderline significance: P value = 0.05
+Including continuous variables of age, diabetes duration, and HbA1c; and categorical variables of gender, smoking status, hypertension, major adverse cardiac events, ankle-brachial index, renal function and LEA status
HR hazard ratio, ABI ankle-brachial index, eGFR estimated glomerular filtration rate, LEA lower-extremity amputation