Table 2.
Clinical characteristics of the patients with diabetes and infectious foot gangrene with different LEA status
| Characteristic | Mean (standard deviation) or Number (%) | ||||
|---|---|---|---|---|---|
| Minor LEA (n = 67) |
Major LEA (n = 90) |
P value | |||
| Death | 38 | 48 | |||
| Median survival time (years) | 5.5 (95% CI: 2.58–8.42) | 1.9 (95% CI: 1.15–2.65) | <0.01* | ||
| 5-year survival rate | 54% | 30% | |||
| Age (years) | 65.8 | (±11.7) | 67.6 | (±10.1) | 0.32 |
| Gender | 0.56 | ||||
| Female | 23 | (34.3%) | 35 | (38.9%) | |
| Male | 44 | (65.7%) | 55 | (61.1%) | |
| Diabetes duration (years) | 11.9 | (±8.9) | 13.5 | (±8.1) | 0.24 |
| Smoking status | 18 | (26.9%) | 16 | (17.8%) | 0.17 |
| Hypertension | 44 | (65.7%) | 67 | (74.4%) | 0.23 |
| Major adverse cardiac events | 17 | (25.4%) | 35 | (38.9%) | 0.08 |
| Abnormal ABI | 32 | (47.8%) | 72 | (80.0%) | <0.01* |
| Renal function | 0.09 | ||||
| Normal renal function (eGFR ≥60) |
31 | (46.3%) | 27 | (30.0%) | |
| Chronic kidney disease (eGFR <60) |
23 | (34.3%) | 36 | (40.0%) | |
| Dialysis | 13 | (19.4%) | 27 | (30.0%) | |
| HbA1c (%) | 9.7 | (±2.5) | 9.0 | (±2.9) | 0.14 |
| Hospitalization duration (days) | 48.2 | (±34.7) | 36.9 | (±25.2) | 0.03* |
*Significance: P value <0.05
+Including continuous variables of age and diabetes duration; and categorical variables of gender, smoking status, hypertension, major adverse cardiac events, ankle-brachial index, and renal function
LEA lower-extremity amputation, ABI ankle-brachial index, eGFR estimated glomerular filtration rate