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. 2018 Jan 4;18:28. doi: 10.1186/s12885-017-3978-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ATRA up-regulates differentiation markers ROBO2 and STMN4 and down-regulated the stem cell marker KLF4 in IMR-32 and BE(2)C cells. Relative mRNA levels for the target genes was determined by qPCR. a Graph displays the level of target gene expression in BE(2)C and IMR-32 cells after 3 days of ATRA (RA) treatment (10 μM) relative to DMSO treated cells, b shows the change in expression after 6 days of treatment with RA. Each bar in the graph represents the mean of technical replicates and three biological repeats. Error bars are SE (T-test). * p < 0.05, ** p < 0.01, *** p < 0.001