Fig. 3.
Effects of acute nicotine (0.09 and 0.36 mg/kg) on contextual encoding in adult and adolescent mice (n=7–10). Upper Panel: Adolescent mice (PND 38) showed CPFE in the saline treated groups with 15 day delay but only showed acute nicotine enhancement of CPFE only at the highest dose (0/36 mg/kg). Lower Panel: Adult mice (PND 53) showed both basic CPFE in the saline treated mice with 15 day delay and the acute nicotine-induced enhancement of CPFE at all three nicotine doses. Error bars indicate Standard Error of the Mean (SEM) and asterisks represent differences from the saline group at the p<0.05 level.